GLP-1 receptor agonists

Thompson says many of his patients microdose GLP-1 drugs for maintenance, which he views as a form of personalized medicine.

“I was like, wow, that's actually, that's a great idea. So a lot of my patients actually do microdose these things”

Huberman Lab: Best Tools for Gut Health & Weight Loss | Dr. Chris Thompson (Sep 21, 2026) · Listen from 35:23

Thompson warns that cycling on and off GLP-1 drugs shifts body composition toward more fat and less muscle each cycle.

“So now basically you're taking your body composition and shifting it worse every cycle. So there has to be a game plan”

Huberman Lab: Best Tools for Gut Health & Weight Loss | Dr. Chris Thompson (Sep 21, 2026) · Listen from 34:31

Thompson reports that about 30% of patients stop GLP-1 drugs in the first month and about half by year's end, similar to other chronic medications.

“About 30% come off GLP-1s in the first month and then 50% or so by the end of the year, right?”

Huberman Lab: Best Tools for Gut Health & Weight Loss | Dr. Chris Thompson (Sep 21, 2026) · Listen from 31:30

Huberman suggests biology favors combinatorial approaches like retatrutide over pushing hard on a single lever.

“maybe the more combinatorial approach is the better approach. I'm speculating here, but there seems to be a parallel theme”

Huberman Lab: Best Tools for Gut Health & Weight Loss | Dr. Chris Thompson (Sep 21, 2026) · Listen from 2:13:47

Huberman said patients now trust their own experience over authority figures, forcing physicians to listen to them.

“People will always trust their experience more than someone else”

The Joe Rogan Experience: #2553 - Andrew Huberman (Sep 14, 2026) · Listen from 2:10:21

Tatro argues Ozempic makes sense for people wanting to lose weight but makes already-fit people look gaunt.

“But if you're already in okay shape and you're taking it, you just look vacuum sealed”

Pardon My Take: Jimmy Tatro, Open Champion Winner Ryan Fox, LeBron Will Never Make A Decision, Mt Rushmore Of Non Edible Things That Look Delicious + FAQ’s (Jul 22, 2026) · Listen from 1:31:02

Tatro says he has not taken and does not plan to take Ozempic, citing unknown side effects.

“I can confirm I have not taken Ozempic. I don't plan on taking Ozempic. It seems like one of those things where it's like side effects TBD”

Pardon My Take: Jimmy Tatro, Open Champion Winner Ryan Fox, LeBron Will Never Make A Decision, Mt Rushmore Of Non Edible Things That Look Delicious + FAQ’s (Jul 22, 2026) · Listen from 1:29:54

Rogan said he supports GLP-1 drugs for dangerously obese people but thinks everyone else should rely on work and exercise.

“if there's a way where massively obese people that are dying can get healthy and it's a GLP-1, I'm all for it”

The Joe Rogan Experience: JRE MMA Show #180 with Daniel Rodriguez (Jun 2, 2026) · Listen from 1:48:55

Rogan argued that the bone and muscle loss attributed to GLP-1 drugs is the same as what happens from starvation.

“These things that you're getting, these side effects of like bone loss and muscle loss, that's what would happen if you just stopped eating too”

The Joe Rogan Experience: JRE MMA Show #180 with Daniel Rodriguez (Jun 2, 2026) · Listen from 1:44:26

Eisenberg says weight loss by any means, including GLP-1 drugs and bariatric surgery, can raise testosterone.

“Bariatric surgery reliably increases testosterone. So I think any way you can lose weight, you know, kind of getting an ideal body weight, I think that's really going to be crucial”

The Mel Robbins Podcast: The Ultimate Guide to Male Hormones & Men’s Health (Oct 8, 2026) · Listen from 18:44

Schoeff argues GLP-1 drugs are metabolic tools rather than weight-loss drugs.

“GLPs are not weight loss drugs. That's just the most disturbing misrepresentation. They're not weight loss drugs. They're metabolic tools, period”

Habits and Hustle: Episode 595: Dr. Jonathan Schoeff: Biohacking for Longevity: What Works, What's Overhyped, and What Matters (Oct 6, 2026) · Listen from 45:20

Rosen said GLP-1 drugs have revolutionized cardiovascular medicine through effects on blood pressure, cholesterol, inflammation and blood sugar.

“GLP-1s are, you know, truly revolutionized healthcare and cardiovascular medicine”

Next Question with Katie Couric: The Art Of Aging: The Heart Of The Matter (Oct 6, 2026) · Listen from 30:16

Sulek says he hasn't tried GLP-1s because his appetite makes dieting manageable.

“I'm kind of right in the, I call it a sweet spot of diet”

Modern Wisdom: How To Go Hard, Even When You Don’t Want To - Sam Sulek - #1157 (Oct 1, 2026) · Listen from 1:36:49

Frisella says he distrusts Ozempic and similar drugs, expecting that rapid short-term results will bring long-term harms.

“anything that comes with short-term gain like that has long-term bad implications”

REAL AF with Andy Frisella: 1064. Andy & DJ CTI: Iran Terror Plot Fears, Nor'easter Slams East Coast & Rising NASCAR Star Attacked (Sep 29, 2026) · Listen from 53:40

Joseph reports a recent study finding smell unchanged in people taking GLP-1 medications, with differences appearing in detection thresholds and reduced food noise.

“everybody assumes that these medications make food taste bad or taste like nothing. And that's not what this group of investigators found. Smell was unchanged”

TED Radio Hour: Big mysteries explained through your senses (Sep 18, 2026) · Listen from 39:37

Goldhill argues that weight-loss drug prices fell because insurers did not cover them, forcing direct-to-consumer sales.

“The insurers didn't cover them, and the prices came down. There's an important lesson to that, right?”

Proven Podcast: Healthcare Fixed: No Insurance Needed, Same Doctors, 60% Less - David Goldhill (Sep 9, 2026) · Listen from 18:48

Claudia Oshry argued GLP-1 drugs undermined the body-positivity movement Lizzo represented because most people chose to lose weight when given the option.

“most people took the drug because while yes, we're embracing fat and fat is beautiful, it's not our first choice”

The Toast: Bloodlines: Wednesday, June 24th, 2026 (Jun 24, 2026) · Listen from 50:26