Saranya Wyles
Mayo Clinic dermatologist and physician-scientist who studies regenerative dermatology and skin aging
Saranya Wyles (Mayo Clinic dermatologist and physician-scientist who studies regenerative dermatology and skin aging) has appeared as a guest on 1 episode in TMT. Topics they speak about most include Sunscreen, Peptide therapy, Diet and skin health.
In their words
Positions and remarks grouped by topic, each with the exact quote and where it was said.
Sunscreen
Wyles advises keeping sunscreen in the car because UV rays penetrate even tinted windows during commutes.
“Even if it's tinted, you should still apply sunscreen in your car”
The Mel Robbins Podcast: Mayo Clinic Dermatologist: 5 Daily Habits That Are Aging Your Skin Faster & What to Do Instead (Oct 19, 2026) · Listen from 1:07:05
Wyles demonstrates that coconut oil and beef tallow offer no UV protection and may increase burn risk.
“You actually have a higher risk for burning with coconut oil and beef tallow”
The Mel Robbins Podcast: Mayo Clinic Dermatologist: 5 Daily Habits That Are Aging Your Skin Faster & What to Do Instead (Oct 19, 2026) · Listen from 1:06:12
Peptide therapy
Wyles does not recommend the injectable Glow Stack peptide combination and instead advises topical copper peptides.
“So that stack is something that I don't recommend. Instead, I say use a topical copper peptides”
The Mel Robbins Podcast: Mayo Clinic Dermatologist: 5 Daily Habits That Are Aging Your Skin Faster & What to Do Instead (Oct 19, 2026) · Listen from 1:00:28
Wyles warns that injecting unregulated peptides outside clinical trials amounts to self-experimentation.
“Anecdotally, we're hearing benefit, but we can't generalize that and provide guidelines without having clinical trials”
The Mel Robbins Podcast: Mayo Clinic Dermatologist: 5 Daily Habits That Are Aging Your Skin Faster & What to Do Instead (Oct 19, 2026) · Listen from 59:05
Diet and skin health
Wyles says drinking water alone does not hydrate the skin barrier and that moisturizer must also be applied.
“the myth around hydrating your skin is that people think drinking water is enough to hydrate their skin barrier”
The Mel Robbins Podcast: Mayo Clinic Dermatologist: 5 Daily Habits That Are Aging Your Skin Faster & What to Do Instead (Oct 19, 2026) · Listen from 40:10
Wyles cites a 12-week randomized trial in which a low-glycemic diet produced a 23% improvement in acne flares.
“they found that these patients had a 23% improvement in their acne flares just by switching their diet”
The Mel Robbins Podcast: Mayo Clinic Dermatologist: 5 Daily Habits That Are Aging Your Skin Faster & What to Do Instead (Oct 19, 2026) · Listen from 30:50
Sleep and skin repair
Wyles reports that just two consecutive nights of three to four hours of sleep disrupt the skin barrier.
“two consecutive nights of three to four hours of sleep disrupts your skin barrier”
The Mel Robbins Podcast: Mayo Clinic Dermatologist: 5 Daily Habits That Are Aging Your Skin Faster & What to Do Instead (Oct 19, 2026) · Listen from 22:33
Wyles explains that skin runs on a circadian clock, defending during the day and repairing at night, making sleep critical for skin health.
“So your skin doesn't sleep at night. It actually shifts into repair mode. And this is why sleep is critical for skin health”
The Mel Robbins Podcast: Mayo Clinic Dermatologist: 5 Daily Habits That Are Aging Your Skin Faster & What to Do Instead (Oct 19, 2026) · Listen from 23:18
Facial jowls and bone loss
Wyles explains that jowls are mainly a structural descent problem driven by bone loss rather than a skin problem.
“Because what you are seeing is a descent problem. It's a gravity problem”
The Mel Robbins Podcast: Mayo Clinic Dermatologist: 5 Daily Habits That Are Aging Your Skin Faster & What to Do Instead (Oct 19, 2026) · Listen from 1:12:33
GLP-1 receptor agonists
Wyles states that every 20 pounds lost on GLP-1 medication corresponds to about 10% facial volume loss.
“For every 20 pounds of weight that you lose on a GLP-1 medications, that's a 10% facial volume loss”
The Mel Robbins Podcast: Mayo Clinic Dermatologist: 5 Daily Habits That Are Aging Your Skin Faster & What to Do Instead (Oct 19, 2026) · Listen from 1:15:46
Stress and hair loss
Wyles explains that stress-related hair shedding typically appears three to four months after a stressful event and is reversible.
“it'll take about three or four months to be reflected on your skin and your hair”
The Mel Robbins Podcast: Mayo Clinic Dermatologist: 5 Daily Habits That Are Aging Your Skin Faster & What to Do Instead (Oct 19, 2026) · Listen from 53:09
Resistance training
Wyles says resistance training plays a bigger role than cardio in skin elasticity and recommends it for patients on GLP-1 medications.
“It's a combination, but resistance training plays the bigger role”
The Mel Robbins Podcast: Mayo Clinic Dermatologist: 5 Daily Habits That Are Aging Your Skin Faster & What to Do Instead (Oct 19, 2026) · Listen from 48:11
Skin aging
Wyles recommends tub moisturizers over pump lotions because pump formulas contain added water and evaporate faster.
“You also want to look for moisturizers that are tub lotions that you can scoop out versus pump lotions”
The Mel Robbins Podcast: Mayo Clinic Dermatologist: 5 Daily Habits That Are Aging Your Skin Faster & What to Do Instead (Oct 19, 2026) · Listen from 42:46
Magnesium supplementation
Wyles recommends magnesium L-threonate taken one to two hours before bed for sleep and skin matrix support.
“So magnesium threonate is the one that helps with sleep, especially”
The Mel Robbins Podcast: Mayo Clinic Dermatologist: 5 Daily Habits That Are Aging Your Skin Faster & What to Do Instead (Oct 19, 2026) · Listen from 28:41
Psoriasis
Wyles cites a study finding that severe psoriasis carries roughly a six-fold increase in 10-year risk of heart disease and heart events.
“if you have severe psoriasis, you're at about six-fold increased risk to your 10-year heart disease and heart event risk”
The Mel Robbins Podcast: Mayo Clinic Dermatologist: 5 Daily Habits That Are Aging Your Skin Faster & What to Do Instead (Oct 19, 2026) · Listen from 6:46
Skin as an indicator of systemic health
Wyles argues that skin is a two-way conduit reflecting internal health and that changes in it should be treated as health information rather than vanity.
“Your skin is more than a beauty scorecard. It is actually information. It's a two-way conduit between the outside world and the internal systemic health”
The Mel Robbins Podcast: Mayo Clinic Dermatologist: 5 Daily Habits That Are Aging Your Skin Faster & What to Do Instead (Oct 19, 2026) · Listen from 3:28
Appearances
Mayo Clinic Dermatologist: 5 Daily Habits That Are Aging Your Skin Faster & What to Do InsteadThe Mel Robbins Podcast · Oct 19, 2026 · 1 h 30 min
Mel Robbins and Mayo Clinic dermatologist Dr. Saranya Wyles discuss what skin reveals about overall health and five pillars for healthier skin aging.
Often appears with
- Mel Robbins · 1 shared episode