Jonathan Schoeff
Practicing spine-access surgeon and longevity physician based in Denver; his label also carries a brief opening show-intro clip voiced by Tony Robbins
Jonathan Schoeff (Practicing spine-access surgeon and longevity physician based in Denver; his label also carries a brief opening show-intro clip voiced by Tony Robbins) has appeared as a guest on 1 episode in TMT. Topics they speak about most include Aging, Strength training, Biohacking.
In their words
Positions and remarks grouped by topic, each with the exact quote and where it was said.
Aging
Schoeff argues high performers assemble advisory teams for everything except a healthspan strategy.
“But there's one chair that's always uniformly empty, and that's their healthcare or healthspan strategy”
Habits and Hustle: Episode 595: Dr. Jonathan Schoeff: Biohacking for Longevity: What Works, What's Overhyped, and What Matters (Oct 6, 2026) · Listen from 55:35
Schoeff calls current biological age testing a waste of money and a hustle.
“The way biologic age testing is being used today is just a hustle, right?”
Habits and Hustle: Episode 595: Dr. Jonathan Schoeff: Biohacking for Longevity: What Works, What's Overhyped, and What Matters (Oct 6, 2026) · Listen from 41:34
Schoeff says he is convinced that aging is fundamentally defined by muscle.
“The idea that aging is really defined by muscle. That's where I'm wholly convinced”
Habits and Hustle: Episode 595: Dr. Jonathan Schoeff: Biohacking for Longevity: What Works, What's Overhyped, and What Matters (Oct 6, 2026) · Listen from 16:39
Strength training
Schoeff says he averages 2.3 training sessions per week and believes three to four is the optimal frequency.
“Now, I think the sweet spot's three to four. I think the sweet spot's three to four”
Habits and Hustle: Episode 595: Dr. Jonathan Schoeff: Biohacking for Longevity: What Works, What's Overhyped, and What Matters (Oct 6, 2026) · Listen from 30:42
Schoeff claims exercise is first-line therapy for depression and anxiety in Europe.
“First-line therapy for depression and anxiety in Europe is literally exercise”
Habits and Hustle: Episode 595: Dr. Jonathan Schoeff: Biohacking for Longevity: What Works, What's Overhyped, and What Matters (Oct 6, 2026) · Listen from 28:20
Schoeff recommends that women lift weights heavy enough to reach near failure within seven to nine reps to build strength.
“My point is for a woman, the weight needs to drive pre-failure in that seven to nine rep range”
Habits and Hustle: Episode 595: Dr. Jonathan Schoeff: Biohacking for Longevity: What Works, What's Overhyped, and What Matters (Oct 6, 2026) · Listen from 25:33
Biohacking
Schoeff says he is immediately skeptical of any wellness claim without an objective outcome.
“Any wellness claim that does not have an objective outcome, period”
Habits and Hustle: Episode 595: Dr. Jonathan Schoeff: Biohacking for Longevity: What Works, What's Overhyped, and What Matters (Oct 6, 2026) · Listen from 1:02:09
Schoeff argues that the biohacks that actually make a difference are often free.
“Biohacks that move the needle are often free. That's the moral of the story, okay?”
Habits and Hustle: Episode 595: Dr. Jonathan Schoeff: Biohacking for Longevity: What Works, What's Overhyped, and What Matters (Oct 6, 2026) · Listen from 10:33
Peptide therapy
Schoeff warns that buying research-use-only peptides online effectively indemnifies unregulated sellers.
“When you check the little box on the website for research purposes only, when it's coming from an unknown source, you're literally indemnifying them”
Habits and Hustle: Episode 595: Dr. Jonathan Schoeff: Biohacking for Longevity: What Works, What's Overhyped, and What Matters (Oct 6, 2026) · Listen from 37:33
Schoeff considers tesamorelin the most potent and gold-standard growth hormone secretagogue peptide.
“And then Tessa Moralin is the gold standard. It costs more”
Habits and Hustle: Episode 595: Dr. Jonathan Schoeff: Biohacking for Longevity: What Works, What's Overhyped, and What Matters (Oct 6, 2026) · Listen from 33:40
Therapeutic plasma exchange
Schoeff argues that plasma exchange, though life-saving for antibody-mediated disease, is now sold at a premium without translational research.
“the problem is now we're selling it at a steep premium without any translational research”
Habits and Hustle: Episode 595: Dr. Jonathan Schoeff: Biohacking for Longevity: What Works, What's Overhyped, and What Matters (Oct 6, 2026) · Listen from 8:49
Schoeff says there is no solid human evidence that therapeutic plasma exchange clears endocrine disruptors or microplastics.
“The argument is for things like everything from EDCs, microplastics, right? We have nothing to support that, no solid human evidence”
Habits and Hustle: Episode 595: Dr. Jonathan Schoeff: Biohacking for Longevity: What Works, What's Overhyped, and What Matters (Oct 6, 2026) · Listen from 7:25
Propranolol
Schoeff explains he uses propranolol to blunt the sympathetic nervous system's physical response to anxiety.
“That whole feeling of anxiety is driven by the sympathetic nervous system. All propranolol does is it just disconnects the two”
Habits and Hustle: Episode 595: Dr. Jonathan Schoeff: Biohacking for Longevity: What Works, What's Overhyped, and What Matters (Oct 6, 2026) · Listen from 1:01:10
Sleep
Schoeff says magnesium's sleep benefits are tied to deficiency and advises testing serum levels first.
“Okay, folks, go get your serum magnesium levels tested. Start there”
Habits and Hustle: Episode 595: Dr. Jonathan Schoeff: Biohacking for Longevity: What Works, What's Overhyped, and What Matters (Oct 6, 2026) · Listen from 58:23
Menopause
Schoeff notes that estrogen is the dominant signal for muscle health in women, which drops sharply at menopause.
“in women, the dominant signal for muscle health is estrogen”
Habits and Hustle: Episode 595: Dr. Jonathan Schoeff: Biohacking for Longevity: What Works, What's Overhyped, and What Matters (Oct 6, 2026) · Listen from 49:56
Testosterone replacement therapy
Schoeff says very low testosterone in men is a disease that raises all-cause mortality risk.
“It's an illness that actually increases the risk of all-cause mortality, death, low testosterone”
Habits and Hustle: Episode 595: Dr. Jonathan Schoeff: Biohacking for Longevity: What Works, What's Overhyped, and What Matters (Oct 6, 2026) · Listen from 49:24
Fasting
Schoeff describes fasting one day a week for four to six weeks as his most powerful protocol.
“usually a day a week for four to six weeks. That's really like the powerhouse”
Habits and Hustle: Episode 595: Dr. Jonathan Schoeff: Biohacking for Longevity: What Works, What's Overhyped, and What Matters (Oct 6, 2026) · Listen from 46:55
GLP-1 receptor agonists
Schoeff argues GLP-1 drugs are metabolic tools rather than weight-loss drugs.
“GLPs are not weight loss drugs. That's just the most disturbing misrepresentation. They're not weight loss drugs. They're metabolic tools, period”
Habits and Hustle: Episode 595: Dr. Jonathan Schoeff: Biohacking for Longevity: What Works, What's Overhyped, and What Matters (Oct 6, 2026) · Listen from 45:20
Cold water immersion
Schoeff advises taking cold showers instead of buying a cold plunge.
“Don't waste your money on a cold plunge. Just take a cold shower. Move on”
Habits and Hustle: Episode 595: Dr. Jonathan Schoeff: Biohacking for Longevity: What Works, What's Overhyped, and What Matters (Oct 6, 2026) · Listen from 44:20
Red light therapy
Schoeff says effective red light therapy needs 70 to 100 milliwatts per square centimeter, while most products he measured deliver only two to three.
“So I said 70 to a hundred, that's the magic number. Most are two to three”
Habits and Hustle: Episode 595: Dr. Jonathan Schoeff: Biohacking for Longevity: What Works, What's Overhyped, and What Matters (Oct 6, 2026) · Listen from 42:51
Continuous glucose monitor
Schoeff rates continuous glucose monitors for healthy people as the most worthwhile item discussed because data drives decisions.
“Worth it times 50. The most worth it I've got on this list because data drives decisions”
Habits and Hustle: Episode 595: Dr. Jonathan Schoeff: Biohacking for Longevity: What Works, What's Overhyped, and What Matters (Oct 6, 2026) · Listen from 40:42
Deadlift
Schoeff argues that spinal disc pressure is highest under forced flexion with load, making conventional deadlifts risky for some.
“The biomechanics of the spine favor the amount of pressure on your discs is highest forced flexion under load”
Habits and Hustle: Episode 595: Dr. Jonathan Schoeff: Biohacking for Longevity: What Works, What's Overhyped, and What Matters (Oct 6, 2026) · Listen from 21:31
Appearances
Episode 595: Dr. Jonathan Schoeff: Biohacking for Longevity: What Works, What's Overhyped, and What MattersHabits and Hustle · Oct 6, 2026 · 1 h 5 min
Jen Cohen and surgeon-longevity physician Dr. Jonathan Schoeff sort biohacking trends into worth it or overhyped, covering strength training, peptides, GLP-1s, hormones, and sleep.
Often appears with
- Jen Cohen · 1 shared episode